Synergistic Chondroprotective Effect of α-Tocopherol, Ascorbic Acid, and Selenium as well as Glucosamine and Chondroitin on Oxidant Induced Cell Death and Inhibition of Matrix Metalloproteinase-3—Studies in Cultured Chondrocytes

Synergistic Chondroprotective Effect of α-Tocopherol, Ascorbic Acid, and Selenium as well as Glucosamine and Chondroitin on Oxidant Induced Cell Death and Inhibition of Matrix Metalloproteinase-3—Studies in Cultured Chondrocytes

Overproduction of reactive oxygen species and impaired antioxidant defence accompanied by chronic inflammatory processes may impair joint health. Pro-inflammatory cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor alpha (TNF-α) stimulate the expression of metalloproteinases which deg...

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Bibliographic Details
Main Authors: Anne-Christi Graeser, Katri Giller, Heike Wiegand, Luca Barella, Christine Boesch Saadatmandi, Gerald Rimbach
Format: Article
Language:English
Published: MDPI AG 2009-12-01
Series:Molecules
Subjects:
tocopherol
ascorbic acid
selenium
chondroitin
glucosamine
chondrocytes
oxidative stress
inflammation
metalloproteinases
Online Access:http://www.mdpi.com/1420-3049/15/1/27/

Internet

http://www.mdpi.com/1420-3049/15/1/27/

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