Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

Microglia cells in the brain regulate immune responses, but in ageing can negatively affect brain function. Here the authors show that the chronic presence of type I interferon in aged mouse brain impedes cognitive ability by altering microglia transcriptome and limiting Mef2C, a microglia ‘off’ sig...

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Bibliographic Details
Main Authors: Aleksandra Deczkowska, Orit Matcovitch-Natan, Afroditi Tsitsou-Kampeli, Sefi Ben-Hamo, Raz Dvir-Szternfeld, Amit Spinrad, Oded Singer, Eyal David, Deborah R. Winter, Lucas K. Smith, Alexander Kertser, Kuti Baruch, Neta Rosenzweig, Anna Terem, Marco Prinz, Saul Villeda, Ami Citri, Ido Amit, Michal Schwartz
Format: Article
Language:English
Published: Nature Portfolio 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00769-0

Internet

https://doi.org/10.1038/s41467-017-00769-0

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