Hybrid molecules synergistically mitigate ferroptosis and amyloid-associated toxicities in Alzheimer's disease

Hybrid molecules synergistically mitigate ferroptosis and amyloid-associated toxicities in Alzheimer's disease

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the build-up of extracellular amyloid β (Aβ) plaques and intracellular neurofibrillary tangles (NFTs). Ferroptosis, an iron (Fe)-dependent form of cell death plays a significant role in the multifaceted AD pathogenesis th...

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Bibliographic Details
Main Authors: Dikshaa Padhi, Prayasee Baruah, Madhu Ramesh, Hariharan Moorthy, Thimmaiah Govindaraju
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Redox Biology
Subjects:
Alzheimer's disease
Ferroptosis
Glutathione peroxidase 4
Liquid-liquid phase separation
Hybrid molecules
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724000958

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http://www.sciencedirect.com/science/article/pii/S2213231724000958

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