ULK2 Is a Key Pro-Autophagy Protein That Contributes to the High Chemoresistance and Disease Relapse in FLT3-Mutated Acute Myeloid Leukemia

ULK2 Is a Key Pro-Autophagy Protein That Contributes to the High Chemoresistance and Disease Relapse in FLT3-Mutated Acute Myeloid Leukemia

We recently demonstrated that a small subset of cells in FLT3-mutated acute myeloid leukemia (AML) cell lines exhibit SORE6 reporter activity and cancer stem-like features including chemoresistance. To study why SORE6<sup>+</sup> cells are more chemoresistant than SORE6<sup>−</s...

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Bibliographic Details
Main Authors: Justine Lai, Claire Yang, Chuquan Shang, Will Chen, Michael P. Chu, Joseph Brandwein, Raymond Lai, Peng Wang
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
acute myeloid leukemia
cancer stemness
relapse
autophagy
Online Access:https://www.mdpi.com/1422-0067/25/1/646

Internet

https://www.mdpi.com/1422-0067/25/1/646

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