Shikonin Inhibits APC-mutant Colon Cancer via Wnt/β-catenin Signaling

Objective To identify small molecule inhibitors of APC-mutant colon cancer and provide lead compounds for targeted therapy of colon cancer. MethodsAPC-mutant colon cancer cell lines that stably express 7*Tcf-GFP/SV40-Cherry (7TGC) dual fluorescence reporter system was constructed for small-molecule...

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Bibliographic Details
Main Authors: Lizhe CHEN, Bojun WANG, Qing GONG, Xue ZHANG, Xisong KE
Format: Article
Language:zho
Published: Magazine House of Cancer Research on Prevention and Treatment 2024-06-01
Series:Zhongliu Fangzhi Yanjiu
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Online Access:http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2024.24.0121