Infliximab Inhibits Colitis Associated Cancer in Model Mice by Downregulating Genes Associated with Mast Cells and Decreasing Their Accumulation

Infliximab Inhibits Colitis Associated Cancer in Model Mice by Downregulating Genes Associated with Mast Cells and Decreasing Their Accumulation

Inflammatory bowel diseases (IBDs), such as Crohn’s disease or ulcerative colitis, can be treated with anti TNF-alpha (TNF-α) antibodies (Abs), but they also put patients with IBDs at risk of cancer. We aimed to determine whether the anti TNF-α Ab induces colon cancer development in vitro and in viv...

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Bibliographic Details
Main Authors: Dan-Yang Wang, Shinobu Ohnuma, Hideyuki Suzuki, Masaharu Ishida, Kentaro Ishii, Takashi Hirosawa, Tomoaki Hirashima, Megumi Murakami, Minoru Kobayashi, Katsuyoshi Kudoh, Sho Haneda, Hiroaki Musha, Takeshi Naitoh, Michiaki Unno
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Current Issues in Molecular Biology
Subjects:
inflammatory bowel disease
Crohn’s disease
ulcerative colitis
colitis-associated cancer
TNF-α
anti TNF-α antibody
Online Access:https://www.mdpi.com/1467-3045/45/4/189

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https://www.mdpi.com/1467-3045/45/4/189

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