A terminal selector prevents a Hox transcriptional switch to safeguard motor neuron identity throughout life

A terminal selector prevents a Hox transcriptional switch to safeguard motor neuron identity throughout life

To become and remain functional, individual neuron types must select during development and maintain throughout life their distinct terminal identity features, such as expression of specific neurotransmitter receptors, ion channels and neuropeptides. Here, we report a molecular mechanism that enable...

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Bibliographic Details
Main Authors: Weidong Feng, Yinan Li, Pauline Dao, Jihad Aburas, Priota Islam, Benayahu Elbaz, Anna Kolarzyk, André EX Brown, Paschalis Kratsios
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
neuronal identity
transcription factors
Hox proteins
terminal selectors
UNC-3/Collier/Ebf
Online Access:https://elifesciences.org/articles/50065

Internet

https://elifesciences.org/articles/50065

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