Mechanical barriers and transforming growth factor beta inhibitor on epidural fibrosis in a rabbit laminectomy model

Abstract Background TGF-β has been described as a mediator of fibrosis and scarring. Several studies achieved reduction in experimental scarring through the inhibition of TGF-β. Fibroblasts have been defined as the cell population originating fibrosis, blocking fibroblast invasion may impair epidura...

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Bibliographic Details
Main Authors: Juan N. Albiñana-Cunningham, Purificación Ripalda-Cemboráin, Tania Labiano, José I. Echeveste, Froilán Granero-Moltó, Matías Alfonso-Olmos
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13018-018-0781-6