Mechanical barriers and transforming growth factor beta inhibitor on epidural fibrosis in a rabbit laminectomy model

Mechanical barriers and transforming growth factor beta inhibitor on epidural fibrosis in a rabbit laminectomy model

Abstract Background TGF-β has been described as a mediator of fibrosis and scarring. Several studies achieved reduction in experimental scarring through the inhibition of TGF-β. Fibroblasts have been defined as the cell population originating fibrosis, blocking fibroblast invasion may impair epidura...

Full description

Bibliographic Details
Main Authors: Juan N. Albiñana-Cunningham, Purificación Ripalda-Cemboráin, Tania Labiano, José I. Echeveste, Froilán Granero-Moltó, Matías Alfonso-Olmos
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Epidural fibrosis
Laminectomy
TGF-β
Biomaterials
Online Access:http://link.springer.com/article/10.1186/s13018-018-0781-6

Similar Items

Similar Items