Early Forms of <i>α</i>-Synuclein Pathology Are Associated with Neuronal Complex I Deficiency in the Substantia Nigra of Individuals with Parkinson’s Disease

Early Forms of <i>α</i>-Synuclein Pathology Are Associated with Neuronal Complex I Deficiency in the Substantia Nigra of Individuals with Parkinson’s Disease

Idiopathic Parkinson’s disease (iPD) is characterized by degeneration of the dopaminergic substantia nigra pars compacta (SNc), typically in the presence of Lewy pathology (LP) and mitochondrial respiratory complex I (CI) deficiency. LP is driven by α-synuclein aggregation, morphologically evolving...

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Bibliographic Details
Main Authors: Irene Hana Flønes, Harald Nyland, Dagny-Ann Sandnes, Guido Werner Alves, Ole-Bjørn Tysnes, Charalampos Tzoulis
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Biomolecules
Subjects:
OXPHOS
mitochondria
synucleinopathy
α-synuclein
Lewy-pathology
respiratory chain
Online Access:https://www.mdpi.com/2218-273X/12/6/747

Internet

https://www.mdpi.com/2218-273X/12/6/747

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