ASP-2/Trans-sialidase chimeric protein induces robust protective immunity in experimental models of Chagas’ disease

ASP-2/Trans-sialidase chimeric protein induces robust protective immunity in experimental models of Chagas’ disease

Abstract Immunization with the Amastigote Surface Protein-2 (ASP-2) and Trans-sialidase (TS) antigens either in the form of recombinant protein, encoded in plasmids or human adenovirus 5 (hAd5) confers robust protection against various lineages of Trypanosoma cruzi. Herein we generated a chimeric pr...

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Bibliographic Details
Main Authors: Julia T. Castro, Rory Brito, Natalia S. Hojo-Souza, Bárbara Azevedo, Natalia Salazar, Camila P. Ferreira, Caroline Junqueira, Ana Paula Fernandes, Ronnie Vasconcellos, Jamille M. Cardoso, Rodrigo D. O. Aguiar-Soares, Paula M. A. Vieira, Cláudia M. Carneiro, Bruno Valiate, Cristiane Toledo, Andres M. Salazar, Otávia Caballero, Joseli Lannes-Vieira, Santuza R. Teixeira, Alexandre B. Reis, Ricardo T. Gazzinelli
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-023-00676-0

Internet

https://doi.org/10.1038/s41541-023-00676-0

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