Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progression.
Inactivating mutations in the p53 tumor suppressor gene occur often in the progression of human cancers. p53 inhibits the outgrowth of nascent cancer cells through anti-proliferative actions (including induction of apoptosis or senescence). To test p53 tumor suppressor functions in a novel experimen...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-08-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2721630?pdf=render |