Cell surface GRP78-directed CAR-T cells are effective at treating human pancreatic cancer in preclinical models

Cell surface GRP78-directed CAR-T cells are effective at treating human pancreatic cancer in preclinical models

Pancreatic cancer is a highly lethal solid malignancy with limited treatment options. Chimeric antigen receptor T (CAR-T) cell therapy has been successfully applied to treat hematological malignancies, but faces many challenges in solid tumors. One major challenge is the shortage of tumor-selective...

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Bibliographic Details
Main Authors: Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Translational Oncology
Subjects:
csGRP78
CAR-T
Gemcitabine
Pancreatic cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523323001894

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http://www.sciencedirect.com/science/article/pii/S1936523323001894

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