Influence of variability in the cyclooxygenase pathway on cardiovascular outcomes of nephrosclerosis patients

Abstract Nephrosclerosis patients are at an exceptionally high cardiovascular (CV) risk. We aimed to determine whether genetic variability represented by 38 tag-SNPs in genes of the cyclooxygenase pathway (PTGS1, PTGS2, PTGES, PTGES2 and PTGES3) leading to prostaglandin E2 (PGE2) synthesis, modified...

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Bibliographic Details
Main Authors: Luz M. González, Nicolás R. Robles, Sonia Mota-Zamorano, José M. Valdivielso, Laura González-Rodríguez, Juan López-Gómez, Guillermo Gervasini
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-27343-z