Influence of variability in the cyclooxygenase pathway on cardiovascular outcomes of nephrosclerosis patients

Influence of variability in the cyclooxygenase pathway on cardiovascular outcomes of nephrosclerosis patients

Abstract Nephrosclerosis patients are at an exceptionally high cardiovascular (CV) risk. We aimed to determine whether genetic variability represented by 38 tag-SNPs in genes of the cyclooxygenase pathway (PTGS1, PTGS2, PTGES, PTGES2 and PTGES3) leading to prostaglandin E2 (PGE2) synthesis, modified...

Full description

Bibliographic Details
Main Authors:	Luz M. González, Nicolás R. Robles, Sonia Mota-Zamorano, José M. Valdivielso, Laura González-Rodríguez, Juan López-Gómez, Guillermo Gervasini
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-01-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-022-27343-z

Similar Items

Tag-SNPs in Phospholipase-Related Genes Modify the Susceptibility to Nephrosclerosis and its Associated Cardiovascular Risk
by: Luz M. González, et al.
Published: (2022-05-01)

Genetic Variants in PGE2 Receptors Modulate the Risk of Nephrosclerosis and Clinical Outcomes in These Patients
by: Luz María González, et al.
Published: (2021-08-01)

Polymorphisms in glucose homeostasis genes are associated with cardiovascular and renal parameters in patients with diabetic nephropathy
by: Sonia Mota-Zamorano, et al.
Published: (2022-12-01)

Genetics Variants in the Epoxygenase Pathway of Arachidonic Metabolism Are Associated with Eicosanoids Levels and the Risk of Diabetic Nephropathy
by: Sonia Mota-Zamorano, et al.
Published: (2021-09-01)

Diagnosis of nephrosclerosis in autopsied deceased
by: Juan Castañer Moreno, et al.
Published: (2021-01-01)

A Custom Target Next-Generation Sequencing 70-Gene Panel and Replication Study to Identify Genetic Markers of Diabetic Kidney Disease
by: Sonia Mota-Zamorano, et al.
Published: (2021-12-01)

Hypertensive Nephrosclerosis Pathogenesis, Diagnosis and Management
by: Meyrier Alain
Published: (1999-01-01)

EFFECTS OF MEVALONATE PATHWAY MODULATORS UPON REACTIVITY OF MACROPHAGES IN E XPERIMENTAL NEPHROSCLEROSIS
by: Ya. Sh. Schwarz, et al.
Published: (2014-07-01)

Polymorphisms in vasoactive eicosanoid genes of kidney donors affect biopsy scores and clinical outcomes in renal transplantation.
by: Sonia Mota-Zamorano, et al.
Published: (2019-01-01)

Bone Morphogenetic Protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis
by: Cohen Clemens D, et al.
Published: (2010-11-01)

Pathogenic basis and modern prospects in early diagnostics of nephrosclerosis in children with vesicoureteral reflux
by: Lakomova D.Y., et al.
Published: (2011-03-01)

Effect of Proteinuria and Glomerular Filtration Rate on Renal Outcome in Patients with Biopsy-Proven Benign Nephrosclerosis.
by: Keiichi Sumida, et al.
Published: (2016-01-01)

Molecular factors of angiogenesis in renal tissue of patients with chronic glomerulonephritis: association with nephrosclerosis and anemia
by: Mikhail Yur'evich Shvetsov, et al.
Published: (2009-08-01)

Clinical Phenotypes and Long-term Prognosis in White Patients With Biopsy-Verified Hypertensive Nephrosclerosis
by: Marius A. Øvrehus, et al.
Published: (2020-03-01)

Cyclooxygenase-2 in Cardiovascular Biology
by: Joseph F. Murphy
Published: (2008-01-01)

Comparative analysis of hypertensive nephrosclerosis in animal models of hypertension and its relevance to human pathology. Glomerulopathy
by: Alex A. Gutsol, et al.
Published: (2022-01-01)

Tamoxifen associated to the conservative CKD treatment promoted additional antifibrotic effects on experimental hypertensive nephrosclerosis
by: Camilla Fanelli, et al.
Published: (2023-08-01)

Cardiovascular risk and inhibition of cyclooxygenase: traditional nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors
by: M. Campanini, et al.
Published: (2013-05-01)

Prognostic Significance of Amino Acid and Biogenic Amines Profiling in Chronic Kidney Disease
by: Guillermo Gervasini, et al.
Published: (2023-10-01)

Gene Expression Studies and Targeted Metabolomics Reveal Disturbed Serine, Methionine, and Tyrosine Metabolism in Early Hypertensive Nephrosclerosis
by: Marius A. Øvrehus, et al.
Published: (2019-02-01)

Transcriptomic analysis reveals partial epithelial–mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathy
by: Ole Petter Nordbø, et al.
Published: (2023-10-01)

Selective cyclooxygenase 2 inhibitors, aspirin, and cardiovascular disease: a reappraisal.
by: Baigent, C, et al.
Published: (2003)

Editorial: Risk of cardiovascular events and cyclooxygenase-2 inhibitors ||FREE PAPER||
by: Reza Tabrizchi
Published: (2006-06-01)

Nociceptors in cardiovascular functions: complex interplay as a result of cyclooxygenase inhibition
by: Raisinghani Manish, et al.
Published: (2006-08-01)

Piperine Reduces Neoplastic Progression in Cervical Cancer Cells by Downregulating the Cyclooxygenase 2 Pathway
by: Luana Pereira Cardoso, et al.
Published: (2023-01-01)

Role of the Cyclooxygenase Pathway in the Association of Obstructive Sleep Apnea and Cancer
by: César Picado, et al.
Published: (2020-10-01)

Effects of kynurenic acid and choline on lipopolysaccharide-induced cyclooxygenase pathway
by: Baris Elif, et al.
Published: (2023-06-01)

Simultaneous inhibition of EGFR/VEGFR and cyclooxygenase-2 targets stemness-related pathways in colorectal cancer cells.
by: Araceli Valverde, et al.
Published: (2015-01-01)

Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in normal and pathological human oral mucosa
by: Annamaria Mauro, et al.
Published: (2010-04-01)

Expression of cyclooxygenase-1 and cyclooxygenase-2 in normal and pathological human oral mucosa.
by: Francesco Burruano, et al.
Published: (2011-04-01)

Role of Cyclooxygenase-2 Pathway in Creating an Immunosuppressive Microenvironment and in Initiation and Progression of Wilms' Tumor
by: Paramahamsa Maturu, et al.
Published: (2017-03-01)

Combined Effects of Cyclooxygenase-1 and Cyclooxygenase-2 Selective Inhibitors on Ovarian Carcinoma in Vivo
by: Jun Zhang, et al.
Published: (2011-01-01)

Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice
by: Scheff Stephen W, et al.
Published: (2009-08-01)

Cyclooxygenases: structural and functional insights
by: Carol A. Rouzer, et al.
Published: (2009-01-01)

The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation
by: W. E. Longo, et al.
Published: (1998-01-01)

Recent Advances and Remaining Challenges in the Management of Diabetic Kidney Disease
by: Guillermo Gervasini
Published: (2023-04-01)

Effects of Cyclooxygenase Inhibitors on Apoptotic Neuroretinal Cells
by: Anja-Kristina Brust, et al.
Published: (2008-01-01)

Response to Trypanosoma cruzi by Human Blood Cells Enriched with Dentritic Cells Is Controlled by Cyclooxygenase-2 Pathway
by: Sandra C. H. Lonien, et al.
Published: (2017-10-01)

Effect of arachidonic acid metabolism gene on cyclooxygenase P450 pathway in hepatocellular carcinoma of mice
by: NI An-ni, LIANG Qing-yang, YAO Hong-fei, LI Gen-liang, TANG Yu-lian
Published: (2020-08-01)

Acetylcholine produces contractions mediated by the cyclooxygenase pathway in arterial vessels in the Chilean frog (Calyptocephalella gayi)
by: F. A. Moraga, et al.
Published: (2017-05-01)