Upregulation of AT1 Receptor Mediates a Pressor Effect Through ROS-SAPK/JNK Signaling in Glutamatergic Neurons of Rostral Ventrolateral Medulla in Rats With Stress-Induced Hypertension

Upregulation of AT1 Receptor Mediates a Pressor Effect Through ROS-SAPK/JNK Signaling in Glutamatergic Neurons of Rostral Ventrolateral Medulla in Rats With Stress-Induced Hypertension

The present study examined whether angiotensin II (Ang II) mediates the pressor effect through nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species (ROS)-mitogen-activated protein kinase (MAPK) signaling in the glutamatergic neurons of the rostral ventrolateral...

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Bibliographic Details
Main Authors: Liping Jiang, Xuan Zhou, Hongyu Yang, Ruijuan Guan, Yanlei Xin, Jijiang Wang, Linlin Shen, Danian Zhu, Shulan Ma, Jin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Physiology
Subjects:
angiotensin II type 1 receptor
stress-induced hypertension
glutamatergic neurons
rostral ventrolateral medulla
NAPDH oxidase-ROS-SAPK/JNK signaling
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01860/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.01860/full

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