Sustained expression of CYPs and DNA adduct accumulation with continuous exposure to PCB126 and PCB153 through a new delivery method: Polymeric implants

Sustained expression of CYPs and DNA adduct accumulation with continuous exposure to PCB126 and PCB153 through a new delivery method: Polymeric implants

A new delivery method via polymeric implants was used for continuous exposure to PCBs. Female Sprague-Dawley rats received subcutaneous polymeric implants containing PCB126 (0.15% load), PCB153 (5% load), or both, for up to 45 d and release kinetics and tissue distribution were measured. PCB153 tiss...

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Bibliographic Details
Main Authors: Farrukh Aqil, Hua Shen, Jeyaprakash Jeyabalan, Xing Xin, Hans-Joachim Lehmler, Gabriele Ludewig, Larry W. Robertson, Ramesh C. Gupta
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Toxicology Reports
Subjects:
Polychlorinated biphenyls (PCBs)
PCB126 (3,3′,4,4′,5-pentachlorobiphenyl)
PCB153 (2,2′,4,4′,5,5′-hexachlorobiphenyl)
Polymeric implants
DNA adducts
32P-postlabeling
CYPs
Paraoxonase 1 (PON1)
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750014000912

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http://www.sciencedirect.com/science/article/pii/S2214750014000912

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