The Impact of the CTHRSSVVC Peptide Upon Experimental Models of Trypanosoma cruzi Infection

The Impact of the CTHRSSVVC Peptide Upon Experimental Models of Trypanosoma cruzi Infection

Chagas disease (CD), caused by the hemoflagellate protozoan Trypanosoma cruzi, affects more than six million people worldwide and presents an unsatisfactory therapy, based on two nitroderivatives, introduced in clinical medicine for decades. The synthetic peptide, with CTHRSSVVC sequence (PepA), mim...

Full description

Bibliographic Details
Main Authors:	Gabriela Rodrigues Leite, Denise da Gama Jaén Batista, Ana Lia Mazzeti, Rosemeire Aparecida Silva, Ademar Benévolo Lugão, Maria de Nazaré Correia Soeiro
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-05-01
Series:	Frontiers in Cellular and Infection Microbiology
Subjects:	Chagas disease Trypanosoma cruzi experimental chemotherapy CTHRSSVVC peptide immunomodulation
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2022.882555/full

Similar Items

Trypanosoma cruzi antigen detection in blood to assess treatment efficacy and cure in mice models of Chagas disease
by: Fernanda Fortes de Araujo, et al.
Published: (2024-01-01)

The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi
by: Cristiane França da Silva, et al.
Published: (2010-05-01)

Hallmarks of the relationship between host and Trypanosoma cruzi sulfated glycoconjugates along the course of Chagas disease
by: Luciana L. Soprano, et al.
Published: (2023-05-01)

Canine Macrophage DH82 Cell Line As a Model to Study Susceptibility to Trypanosoma cruzi Infection
by: Pedro Henrique Braz Mendonça, et al.
Published: (2017-05-01)

Seroprevalence of Trypanosoma cruzi infection in blood donors in the extreme South of Brazil
by: Tanise Freitas Bianchi, et al.
Published: (2022-04-01)

Effects of severe protein restriction in levels of parasitemia and in mortality of mice accutely infected with Trypanosoma cruzi
by: Nildete G.L. Gomes, et al.
Published: (1994-03-01)

Vaccination with epimastigotes of different strains of Trypanosoma rangeli protects mice against Trypanosoma cruzi infection
by: Beatriz Basso, et al.
Published: (2008-06-01)

Trypanosoma cruzi mucins: potential functions of a complex structure
by: Igor C Almeida, et al.
Published: (1999-09-01)

Implications of genetic variability of Trypanosoma cruzi for the pathogenesis of Chagas disease Implicações da variabilidade genética do Trypanosoma cruzi na patogênese da doença de Chagas
by: Fernanda da Silva Manoel-Caetano, et al.
Published: (2007-10-01)

Implication of Apoptosis for the Pathogenesis of Trypanosoma cruzi Infection
by: Débora Decote-Ricardo, et al.
Published: (2017-05-01)

Synthesis and Anti-Trypanosoma cruzi Activity of Diaryldiazepines
by: Júlio César L. Menezes, et al.
Published: (2014-12-01)

The activity of a metronidazole analogue and its β-cyclodextrin complex against Trypanosoma cruzi
by: Marcela Silva Lopes, et al.
Published: (2011-12-01)

C57BL/6 Mice Pretreated With Alpha-Tocopherol Show a Better Outcome of Trypanosoma cruzi Infection With Less Tissue Inflammation and Fibrosis
by: Amanda C. O. Silva, et al.
Published: (2022-01-01)

Prevalência de triatomíneos (Hemíptera: Reduviidae: Triatominae) infectados por Trypanosoma cruzi: sazonalidade e distribuição na região Ciénega do Estado de Jalisco, México Prevalence of triatomines (Hemíptera: Reduviidae: Triatominae) infected by Trypanosoma cruzi: seasonality and distribution in the Ciénega region of the State of Jalisco, Mexico
by: César Gómez-Hernández, et al.
Published: (2008-06-01)

RADIOLOGICAL STUDY OF MEGACOLON IN TRYPANOSOMA CRUZI INFECTED RATS
by: Carlos Edmundo Rodrigues FONTES, et al.
Published: (2018-03-01)

Infecção tripla por Trypanosoma cruzi, Plasmodium vivax e P. falciparum: relato de caso Triple infection by Trypanosoma cruzi, Plasmodium vivax and P. falciparum: case report
by: Andrea Silvestre Lobão Costa, et al.
Published: (2012-12-01)

Trypanosoma cruzi seroprevalence and associated risk factors in cancer patients from Southern Brazil
by: Luciane d'Avila Rosenthal, et al.

Detection of Trypanosoma cruzi in white-eared opossums (Didelphis albiventris) from Canoinhas, Santa Catarina State, Brazil
by: Giane Helenita Pontarolo, et al.
Published: (2025-02-01)

Amastigotes forms of Trypanosoma cruzi detected in a renal allograft
by: CARVALHO Maria Fernanda C., et al.
Published: (1997-01-01)

In Vitro Evaluation of Arylsulfonamide Derivatives against <i>Trypanosoma cruzi</i>
by: Policarpo Ademar Sales Junior, et al.
Published: (2023-06-01)

Vaccination of dogs with Trypanosoma rangeli induces antibodies against Trypanosoma cruzi in a rural area of Córdoba, Argentina
by: Beatriz Basso, et al.
Published: (2016-04-01)

Action of Trypanosoma rangeli in infections with virulent Trypanosoma cruzi populations
by: MT Paláu, et al.
Published: (2003-06-01)

Reaching for the Holy Grail: insights from infection/cure models on the prospects for vaccines for Trypanosoma cruzi infection
by: Juan Bustamante, et al.
Published: (2015-05-01)

Seroprevalence of Trypanosoma cruzi infection in French Guiana
by: Christine Aznar, et al.
Published: (2004-12-01)

Canine Trypanosoma cruzi infection in the Bolivian Chaco
by: Simona Gabrielli, et al.
Published: (2018-12-01)

Penetração do Trypanosoma cruzi através do ponto da picada de triatomíneos
by: V.A. Soares, et al.
Published: (1986-09-01)

An Update on Vaccines Against <i>Trypanosoma cruzi</i> and Chagas Disease
by: Nisha J. Garg
Published: (2025-01-01)

Natural Trypanosoma cruzi infection in dogs of endemic areas of the Argentine Republic
by: Marta A. Lauricella, et al.
Published: (1989-04-01)

Review on Experimental Treatment Strategies Against Trypanosoma cruzi
by: Mazzeti AL, et al.
Published: (2021-03-01)

Murine virus contaminant of Trypanosoma cruzi experimental infection Virus murino como contaminante na infecção experimental pelo Trypanosoma cruzi
by: Humberto de A. Rangel, et al.
Published: (1994-10-01)

Histological and histoquantitative study of the rat parotid gland after Trypanosoma cruzi infection
by: Silva R.C., et al.
Published: (2000-06-01)

Microbiome Alterations Driven by Trypanosoma cruzi Infection in Two Disjunctive Murine Models
by: Sergio Castañeda, et al.
Published: (2023-06-01)

Inositol metabolism in Trypanosoma cruzi: potential target for chemotherapy against Chagas' disease
by: MECIA M. OLIVEIRA, et al.
Published: (2000-09-01)

Genitourinary changes in hamsters infected and reinfected with Trypanosoma cruzi
by: Cabrine-Santos Marlene, et al.
Published: (2003-01-01)

ANTI-Trypanosoma cruzi ANTIBODIES IN THE INHABITANTS OF URBAN AND RURAL AREAS OF ABADIA DOS DOURADOS, STATE OF MINAS GERAIS, BRAZIL
by: Eleuza Rodrigues MACHADO, et al.
Published: (1998-09-01)

Inter-relation of sylvatic and domestic transmission of Trypanosoma cruzi in areas with and without domestic vectorial transmission in Minas Gerais, Brazil
by: L. Diotaiuti, et al.
Published: (1995-08-01)

Eco-epidemiological aspects of Trypanosoma cruzi, Trypanosoma rangeli and their vector (Rhodnius pallescens) in Panama Generalidades do Trypanosoma cruzi, do Trypanosoma rangeli e do seu vetor (Rhodnius pallescens) no Panamá
by: Ana Maria de Vasquez, et al.
Published: (2004-08-01)

Distribuição e infecção de triatomíneos por Trypanosoma do tipo cruzi na Ilha de São Luís-Maranhão
by: Reginaldo Peçanha Brazil, et al.
Published: (1985-12-01)

Neuronal changes caused by Trypanosoma cruzi: an experimental model
by: Neide M Moreira, et al.
Published: (2011-06-01)

Occurrence of positivity for Trypanosoma cruzi in triatomine from municipalities in Southeastern Brazil, from 2002 to 2004 Ocorrência e positividade para Trypanosoma cruzi em triatomíneos de municípios da região sudeste do Brasil, de 2002 a 2004
by: Márcia Beatriz Cardoso de Paula, et al.
Published: (2010-02-01)