Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration

Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration

Abstract Background Extracellular matrix stiffness is emerging as a crucial mechanical cue that drives the progression of various diseases, such as cancer, fibrosis, and inflammation. The matrix stiffness of the nucleus pulposus (NP) tissues increase gradually during intervertebral disc degeneration...

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Bibliographic Details
Main Authors: Wencan Ke, Bingjin Wang, Zhiwei Liao, Yu Song, Gaocai Li, Liang Ma, Kun Wang, Shuai Li, Wenbin Hua, Cao Yang
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Translational Medicine
Subjects:
Matrix stiffness
Mechanotransduction
Mitochondrial fission
Piezo1
Nucleus pulposus
Intervertebral disc degeneration
Online Access:https://doi.org/10.1186/s12967-023-04590-w

Internet

https://doi.org/10.1186/s12967-023-04590-w

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