Strain specific properties of Escherichia coli can prevent non-canonical amino acid misincorporation caused by scale-related process heterogeneities

Strain specific properties of Escherichia coli can prevent non-canonical amino acid misincorporation caused by scale-related process heterogeneities

Abstract Background Escherichia coli is one of the most important hosts for production of recombinant proteins in biopharmaceutical industry. However, when selecting a suitable production strain, it is often not considered that a lot of different sub-species exist, which can differ in their genotype...

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Bibliographic Details
Main Authors: Florian Mayer, Monika Cserjan-Puschmann, Benedikt Haslinger, Anton Shpylovyi, Thomas Dalik, Christian Sam, Rainer Hahn, Gerald Striedner
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Microbial Cell Factories
Subjects:
Scale-down
Recombinant protein production
Fab
Norleucine misincorporation
Escherichia coli
Online Access:https://doi.org/10.1186/s12934-022-01895-1

Internet

https://doi.org/10.1186/s12934-022-01895-1

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