Mitochondrial Dysfunction Is Inducible in Lymphoblastoid Cell Lines From Children With Autism and May Involve the TORC1 Pathway

Mitochondrial Dysfunction Is Inducible in Lymphoblastoid Cell Lines From Children With Autism and May Involve the TORC1 Pathway

We previously developed a lymphoblastoid cell line (LCL) model of mitochondrial dysfunction in autism spectrum disorder (ASD); some individuals with ASD showed mitochondrial dysfunction (AD-A) while other individuals (AD-N) demonstrated mitochondrial respiration similar to controls (CNT). To test th...

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Bibliographic Details
Main Authors: Sirish C. Bennuri, Shannon Rose, Richard E. Frye
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Psychiatry
Subjects:
autism
mitochondria
mitoplasticity
mechanistic target of rapamycin
reactive oxygen species
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2019.00269/full

Internet

https://www.frontiersin.org/article/10.3389/fpsyt.2019.00269/full

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