Increased Expression of Mitochondrial UQCRC1 in Pancreatic Cancer Impairs Antitumor Immunity of Natural Killer Cells via Elevating Extracellular ATP

Increased Expression of Mitochondrial UQCRC1 in Pancreatic Cancer Impairs Antitumor Immunity of Natural Killer Cells via Elevating Extracellular ATP

Pancreatic cancer (PC) is one of the most lethal malignancies characterized by a highly immunosuppressive tumor microenvironment (TME). Previously, we have reported that ubiquinol-cytochrome c reductase core protein I (UQCRC1), a key component of mitochondrial complex III, is generally upregulated i...

Full description

Bibliographic Details
Main Authors: Hui Cong, Jian Gao, Qing Wang, Min Du, Huimin Li, Qian Li, Jin Li, Yiyi Liang, Dan Zhao, Hancao Yang, Yu Gan, Hong Tu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
UQCRC1
NK cells
Extracellular adenosine triphosphate
extracellular adenosine
pancreatic cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.872017/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.872017/full

Similar Items