EGFR transactivates RON to drive oncogenic crosstalk

EGFR transactivates RON to drive oncogenic crosstalk

Crosstalk between different receptor tyrosine kinases (RTKs) is thought to drive oncogenic signaling and allow therapeutic escape. EGFR and RON are two such RTKs from different subfamilies, which engage in crosstalk through unknown mechanisms. We combined high-resolution imaging with biochemical and...

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Bibliographic Details
Main Authors: Carolina Franco Nitta, Ellen W Green, Elton D Jhamba, Justine M Keth, Iraís Ortiz-Caraveo, Rachel M Grattan, David J Schodt, Aubrey C Gibson, Ashwani Rajput, Keith A Lidke, Bridget S Wilson, Mara P Steinkamp, Diane S Lidke
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-11-01
Series:eLife
Subjects:
EGFR
RON
cell signaling
membrane biophysics
receptor tyrosine kinase
Online Access:https://elifesciences.org/articles/63678

Internet

https://elifesciences.org/articles/63678

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