Preparing anti-SARS-CoV-2 agent EIDD-2801 by a practical and scalable approach, and quick evaluation via machine learning

Preparing anti-SARS-CoV-2 agent EIDD-2801 by a practical and scalable approach, and quick evaluation via machine learning

EIDD-2801 is an orally bioavailable prodrug, which will be applied for emergency use authorization from the U.S. Food and Drug Administration for the treatment of COVID-19. To investigate the optimal parameters, EIDD-2801 was optimized via a four-step synthesis with high purity of 99.9%. The hydroxy...

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Bibliographic Details
Main Authors: Zhen Qin, Bin Dong, Renbing Wang, Dechun Huang, Jubo Wang, Xi Feng, Jinlei Bian, Zhiyu Li
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Acta Pharmaceutica Sinica B
Subjects:
EIDD-2801
SARS-CoV-2
Antiviral drug
Decision tree
Shapley value
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521004032

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http://www.sciencedirect.com/science/article/pii/S2211383521004032

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