Tumor-secreted IFI35 promotes proliferation and cytotoxic activity of CD8+ T cells through PI3K/AKT/mTOR signaling pathway in colorectal cancer

Tumor-secreted IFI35 promotes proliferation and cytotoxic activity of CD8+ T cells through PI3K/AKT/mTOR signaling pathway in colorectal cancer

Abstract Background A large proportion of the patients with cancer do not respond to immunotherapies. Recent studies suggested an important role for tumor-infiltrating cytotoxic T lymphocytes (CTL) in enhancing response to immunotherapy. Here, we aim to identify gene that induce proliferative and cy...

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Bibliographic Details
Main Authors: Peisi Li, Dawang Zhou, Dongwen Chen, Yikan Cheng, Yuan Chen, Zhensen Lin, Xi Zhang, Zhihong Huang, Jiawei Cai, Wenfeng Huang, Yanyun Lin, Haoxian Ke, Jiahui Long, Yifeng Zou, Shubiao Ye, Ping Lan
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Biomedical Science
Subjects:
IFI35
CD8+ T cells
Immunotherapy
Colorectal cancer
Online Access:https://doi.org/10.1186/s12929-023-00930-6

Internet

https://doi.org/10.1186/s12929-023-00930-6

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