PET imaging of an optimized anti-PD-L1 probe 68Ga-NODAGA-BMS986192 in immunocompetent mice and non-human primates

PET imaging of an optimized anti-PD-L1 probe 68Ga-NODAGA-BMS986192 in immunocompetent mice and non-human primates

Abstract Background Adnectin is a protein family derived from the 10th type III domain of human fibronectin (10Fn3) with high-affinity targeting capabilities. Positron emission tomography (PET) probes derived from anti-programmed death ligand-1 (PD-L1) Adnectins, including 18F- and 68Ga-labeled BMS-...

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Bibliographic Details
Main Authors: Huimin Zhou, Guangfa Bao, Ziqiang Wang, Buchuan Zhang, Dan Li, Lixing Chen, Xiaoyun Deng, Bo Yu, Jun Zhao, Xiaohua Zhu
Format: Article
Language:English
Published: SpringerOpen 2022-06-01
Series:EJNMMI Research
Subjects:
PET imaging
68Ga
Adnectin
BMS-986192
PD-L1
Cynomolgus
Online Access:https://doi.org/10.1186/s13550-022-00906-x

Internet

https://doi.org/10.1186/s13550-022-00906-x

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