Population pharmacokinetics model for escitalopram in Chinese psychiatric patients: effect of CYP2C19 and age

Population pharmacokinetics model for escitalopram in Chinese psychiatric patients: effect of CYP2C19 and age

Objective: To establish a population pharmacokinetic model in Chinese psychiatric patients to characterize escitalopram pharmacokinetic profile to identify factors influencing drug exposure, and through simulation to compare the results with the established therapeutic reference range.Methods: Demog...

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Bibliographic Details
Main Authors: Shujing Liu, Tao Xiao, Shanqing Huang, Xiaolin Li, Wan Kong, Ye Yang, Zi Zhang, Xiaojia Ni, Haoyang Lu, Ming Zhang, Dewei Shang, Yuguan Wen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pharmacology
Subjects:
CYP2C19 genotype
elderly
escitalopam
adolescent
population pharmacokinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.964758/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.964758/full

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