Bromodomain Inhibitors Modulate FcγR-Mediated Mononuclear Phagocyte Activation and Chemotaxis

Bromodomain Inhibitors Modulate FcγR-Mediated Mononuclear Phagocyte Activation and Chemotaxis

IgG antibodies form immune complexes (IC) that propagate inflammation and tissue damage in autoimmune diseases such as systemic lupus erythematosus. IgG IC engage Fcγ receptors (FcγR) on mononuclear phagocytes (MNP), leading to widespread changes in gene expression that mediate antibody effector fun...

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Bibliographic Details
Main Authors: Gemma D. Banham, Colin Y. C. Lee, John R. Ferdinand, Rebeccah J. Matthews, Chenzhi Jing, Nicholas Smithers, Rab K. Prinjha, Menna R. Clatworthy
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
BET inhibitors
systemic lupus erythematosus (SLE)
Fcγ-receptor
dendritic cell chemotaxis
antibody-mediated inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.885101/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.885101/full

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