Single-molecule methylation profiles of cell-free DNA in cancer with nanopore sequencing

Single-molecule methylation profiles of cell-free DNA in cancer with nanopore sequencing

Abstract Epigenetic characterization of cell-free DNA (cfDNA) is an emerging approach for detecting and characterizing diseases such as cancer. We developed a strategy using nanopore-based single-molecule sequencing to measure cfDNA methylomes. This approach generated up to 200 million reads for a s...

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Bibliographic Details
Main Authors: Billy T. Lau, Alison Almeda, Marie Schauer, Madeline McNamara, Xiangqi Bai, Qingxi Meng, Mira Partha, Susan M. Grimes, HoJoon Lee, Gregory M. Heestand, Hanlee P. Ji
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Genome Medicine
Subjects:
Methylation
Single-molecule sequencing
Nanopore
Cell-free DNA
Online Access:https://doi.org/10.1186/s13073-023-01178-3

Internet

https://doi.org/10.1186/s13073-023-01178-3

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