A Novel RGD-4C-Saporin Conjugate Inhibits Tumor Growth in Mouse Models of Bladder Cancer

A Novel RGD-4C-Saporin Conjugate Inhibits Tumor Growth in Mouse Models of Bladder Cancer

Although toxin may have some advantages compared to chemotherapeutic drugs in cancer therapy, e.g. a potent cytotoxic activity and a reduced risk of resistance, their successful application in the treatments to solid tumors still remains to be fully demonstrated. In this study, we genetically modifi...

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Bibliographic Details
Main Authors: Stefania Zuppone, Chiara Assalini, Claudia Minici, Oronza A. Botrugno, Flavio Curnis, Massimo Degano, Angelo Corti, Francesco Montorsi, Andrea Salonia, Riccardo Vago
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
saporin
recombinant protein
bladder cancer
RGD peptide
targeted therapy
ribosome inactivating proteins
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.846958/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.846958/full

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