Mammalian gene expression variability is explained by underlying cell state

Abstract Gene expression variability in mammalian systems plays an important role in physiological and pathophysiological conditions. This variability can come from differential regulation related to cell state (extrinsic) and allele‐specific transcriptional bursting (intrinsic). Yet, the relative c...

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Bibliographic Details
Main Authors: Robert Foreman, Roy Wollman
Format: Article
Language:English
Published: Springer Nature 2020-02-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.15252/msb.20199146