Multi-omics approaches reveal that diffuse midline gliomas present altered DNA replication and are susceptible to replication stress therapy

Multi-omics approaches reveal that diffuse midline gliomas present altered DNA replication and are susceptible to replication stress therapy

Abstract Background The fatal diffuse midline gliomas (DMG) are characterized by an undruggable H3K27M mutation in H3.1 or H3.3. K27M impairs normal development by stalling differentiation. The identification of targetable pathways remains very poorly explored. Toward this goal, we undertake a multi...

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Bibliographic Details
Main Authors: Anastasia E. Hains, Kashish Chetal, Tsunetoshi Nakatani, Joana G. Marques, Andreas Ettinger, Carlos A. O. Biagi Junior, Adriana Gonzalez-Sandoval, Renjitha Pillai, Mariella G. Filbin, Maria-Elena Torres-Padilla, Ruslan I. Sadreyev, Capucine Van Rechem
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Genome Biology
Subjects:
Diffuse midline gliomas H3 K27-altered
H3K27M
Cell cycle
Replication timing
Replication stress
Online Access:https://doi.org/10.1186/s13059-024-03460-y

Internet

https://doi.org/10.1186/s13059-024-03460-y

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