A Mouse Model of Ulcerative Cutaneous Leishmaniasis by Leishmania (Viannia) panamensis to Investigate Infection, Pathogenesis, Immunity, and Therapeutics

A Mouse Model of Ulcerative Cutaneous Leishmaniasis by Leishmania (Viannia) panamensis to Investigate Infection, Pathogenesis, Immunity, and Therapeutics

A mouse model of cutaneous leishmaniasis (CL) by Leishmania (Viannia) panamensis (L(V)p) that reproduces the characteristics of the human disease remains elusive. Here we report the development of a CL model that uses a mouse-adapted L(V)p isolate to reproducibly induce a dermal disease with a remar...

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Bibliographic Details
Main Authors: Natalia Muñoz-Durango, Alexander Gómez, Natalia García-Valencia, Miguel Roldán, Marcela Ochoa, David E. Bautista-Erazo, José R. Ramírez-Pineda
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Microbiology
Subjects:
cutaneous leishmaniasis
Leishmania (Viannia) panamensis
mouse model
vaccine
immunopathology
forward vaccinology
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.907631/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.907631/full

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