CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion.

CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion.

In our work, we analyzed the role of the CD100/CD72 and PD-1/PD-L1 axes in immune response dysfunction in human immunodeficiency virus (HIV)-1 infection in which high expressions of PD-1 and PD-L1 were associated with an immunosuppressive state via limitation of the HIV-1-specific T-cell responses....

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Bibliographic Details
Main Authors: Rafael Correa-Rocha, Jacobo Lopez-Abente, Carolina Gutierrez, Verónica Astrid Pérez-Fernández, Adrián Prieto-Sánchez, Santiago Moreno-Guillen, María-Ángeles Muñoz-Fernández, Marjorie Pion
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6117071?pdf=render

Internet

http://europepmc.org/articles/PMC6117071?pdf=render

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