Microglia Regulate Blood–Brain Barrier Integrity via MiR‐126a‐5p/MMP9 Axis during Inflammatory Demyelination

Microglia Regulate Blood–Brain Barrier Integrity via MiR‐126a‐5p/MMP9 Axis during Inflammatory Demyelination

Abstract Blood–brain barrier (BBB) impairment is an early prevalent feature of multiple sclerosis (MS), and remains vital for MS progression. Microglial activation precedes BBB disruption and cellular infiltrates in the brain of MS patients. However, little is known about the function of microglia i...

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Bibliographic Details
Main Authors: Zhongwang Yu, Xue Fang, Weili Liu, Rui Sun, Jintao Zhou, Yingyan Pu, Ming Zhao, Dingya Sun, Zhenghua Xiang, Peng Liu, Yuqiang Ding, Li Cao, Cheng He
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Advanced Science
Subjects:
blood–brain barrier
experimental autoimmune encephalomyelitis
microglia
miR‐126a‐5p
multiple sclerosis
Online Access:https://doi.org/10.1002/advs.202105442

Internet

https://doi.org/10.1002/advs.202105442

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