Microphysiological Conditions Do Not Affect MDR1-Mediated Transport of Rhodamine 123 above an Artificial Proximal Tubule

Microphysiological Conditions Do Not Affect MDR1-Mediated Transport of Rhodamine 123 above an Artificial Proximal Tubule

Despite disadvantages, such as high cost and their poor predictive value, animal experiments are still the state of the art for pharmaceutical substance testing. One reason for this problem is the inability of standard cell culture methods to emulate the physiological environment necessary to recapi...

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Bibliographic Details
Main Authors: Negin Namazian Jam, Felix Gottlöber, Melanie Hempel, Yuliya Dzekhtsiarova, Stephan Behrens, Frank Sonntag, Jan Sradnick, Christian Hugo, Florian Schmieder
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Biomedicines
Subjects:
proximal tubule
multidrug resistance protein 1 (MDR1)
transport kinetics
tariquidar
microphysiological systems
rhodamine 123
Online Access:https://www.mdpi.com/2227-9059/11/7/2045

Internet

https://www.mdpi.com/2227-9059/11/7/2045

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