Chromatin landscape, DSB levels, and cKU-70/80 contribute to patterning of meiotic DSB processing along chromosomes in C. elegans.

Programmed DNA double-strand break (DSB) formation is essential for achieving accurate chromosome segregation during meiosis. DSB repair timing and template choice are tightly regulated. However, little is known about how DSB distribution and the choice of repair pathway are regulated along the leng...

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Bibliographic Details
Main Authors: Laura I Lascarez-Lagunas, Marina Martinez-Garcia, Saravanapriah Nadarajan, Brianna N Diaz-Pacheco, Elizaveta Berson, Mónica P Colaiácovo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010627