Subantimicrobial Dose Doxycycline Worsens Chronic Arthritis-Induced Bone Microarchitectural Alterations in a Mouse Model: Role of Matrix Metalloproteinases?

Subantimicrobial Dose Doxycycline Worsens Chronic Arthritis-Induced Bone Microarchitectural Alterations in a Mouse Model: Role of Matrix Metalloproteinases?

Background: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease hallmarked by irreversible damage of cartilage and bone. Matrix metalloproteinases (MMPs) involved in connective tissue remodeling play an important role in this process. Numerous MMPs have been examined in humans and anim...

Full description

Bibliographic Details
Main Authors: Ádám Horváth, Bálint Botz, Tamás Kiss, Kata Csekő, Ibolya Kiss, Attila Felinger, Tamara Szabados, Éva Kenyeres, Péter Bencsik, Attila Mócsai, Péter Ferdinandy, Zsuzsanna Helyes
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pharmacology
Subjects:
rheumatoid arthritis
matrix metalloproteinases
K/BxN serum-transfer arthritis
subantimicrobial dose doxycycline
bone homeostasis
in vivo optical imaging
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00233/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00233/full

Similar Items