Depletion of DNA Polymerase Theta Inhibits Tumor Growth and Promotes Genome Instability through the cGAS-STING-ISG Pathway in Esophageal Squamous Cell Carcinoma

Depletion of DNA Polymerase Theta Inhibits Tumor Growth and Promotes Genome Instability through the cGAS-STING-ISG Pathway in Esophageal Squamous Cell Carcinoma

Overexpression of the specialized DNA polymerase theta (POLQ) is frequent in breast, colon and lung cancers and has been correlated with unfavorable clinical outcomes. Here, we aimed to determine the importance and functional role of POLQ in esophageal squamous cell carcinoma (ESCC). Integrated anal...

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Bibliographic Details
Main Authors: Jian Li, Josephine Mun-Yee Ko, Wei Dai, Valen Zhuoyou Yu, Hoi Yan Ng, Jean-Sébastien Hoffmann, Maria Li Lung
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
POLQ
genomic instability
innate immune response
Online Access:https://www.mdpi.com/2072-6694/13/13/3204

Internet

https://www.mdpi.com/2072-6694/13/13/3204

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