The Role of METTL3-Mediated N6-Methyladenosine (m6A) of JPH2 mRNA in Cyclophosphamide-Induced Cardiotoxicity

The Role of METTL3-Mediated N6-Methyladenosine (m6A) of JPH2 mRNA in Cyclophosphamide-Induced Cardiotoxicity

Cyclophosphamide (CYP)-induced cardiotoxicity is a common side effect of cancer treatment. Although it has received significant attention, the related mechanisms of CYP-induced cardiotoxicity remain largely unknown. In this study, we used cell and animal models to investigate the effect of CYP on ca...

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Bibliographic Details
Main Authors: Min Zhu, Yangong Liu, Yuanxiu Song, Shiqin Zhang, Chengwen Hang, Fujian Wu, Xianjuan Lin, Zenghui Huang, Feng Lan, Ming Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
cyclophosphamide
cardiotoxicity
JPH2
m6A methylation
METTL3
cardiomyocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.763469/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.763469/full

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