Pathophysiological Role and Diagnostic Potential of R-Loops in Cancer and Beyond

Pathophysiological Role and Diagnostic Potential of R-Loops in Cancer and Beyond

R-loops are DNA–RNA hybrids that play multifunctional roles in gene regulation, including replication, transcription, transcription–replication collision, epigenetics, and preserving the integrity of the genome. The aberrant formation and accumulation of unscheduled R-loops can disrupt gene expressi...

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Bibliographic Details
Main Authors: Essak S. Khan, Sven Danckwardt
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Genes
Subjects:
R-loop
co-transcriptional processing
transcription termination
(alternative) polyadenylation
human disease
biomarker
Online Access:https://www.mdpi.com/2073-4425/13/12/2181

Internet

https://www.mdpi.com/2073-4425/13/12/2181

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