Alteration in Mir-21/PTEN expression modulates gefitinib resistance in non-small cell lung cancer.

Alteration in Mir-21/PTEN expression modulates gefitinib resistance in non-small cell lung cancer.

Resistance to TKI treatment is a major obstacle in effective treatment of NSCLC. Besides EGFR mutation status, the mechanisms involved are largely unknown. Some evidence supports a role for microRNA 21 in modulating drug sensitivity of chemotherapy but its role in NSCLC TKI resistance still remains...

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Bibliographic Details
Main Authors: Hua Shen, Fang Zhu, Jinyuan Liu, Tongpeng Xu, Dong Pei, Rong Wang, Yingying Qian, Qi Li, Lin Wang, Zhumei Shi, Jitai Zheng, Qiudan Chen, Binghua Jiang, Yongqian Shu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4110008?pdf=render

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http://europepmc.org/articles/PMC4110008?pdf=render

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