HDAC inhibition delays photoreceptor loss in Pde6b mutant mice of retinitis pigmentosa: insights from scRNA-seq and CUT&Tag

HDAC inhibition delays photoreceptor loss in Pde6b mutant mice of retinitis pigmentosa: insights from scRNA-seq and CUT&Tag

Purpose This research aimed to ascertain the neuroprotective effect of histone deacetylase (HDAC) inhibition on retinal photoreceptors in Pde6brd1 mice, a model of retinitis pigmentosa (RP). Methods Single-cell RNA-sequencing (scRNA-seq) explored HDAC and poly (ADP-ribose) polymerase (PARP)-related...

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Bibliographic Details
Main Authors: Yujie Dong, Jie Yan, Wenrong Xu, François Paquet-Durand, Zhulin Hu, Kangwei Jiao
Format: Article
Language:English
Published: PeerJ Inc. 2023-07-01
Series:PeerJ
Subjects:
Retinitis pigmentosa
Hereditary retinal neurodegenerative disorders
Photoreceptor cells
Histone deacetylases
Poly (ADP-ribose) polymerases
Cell death mechanisms
Online Access:https://peerj.com/articles/15659.pdf

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https://peerj.com/articles/15659.pdf

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