Diarachidonoylphosphoethanolamine induces apoptosis of malignant pleural mesothelioma cells through a Trx/ASK1/p38 MAPK pathway

Diarachidonoylphosphoethanolamine induces apoptosis of malignant pleural mesothelioma cells through a Trx/ASK1/p38 MAPK pathway

1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine (DAPE) induces both necrosis/necroptosis and apoptosis of NCI-H28 malignant pleural mesothelioma (MPM) cells. The present study was conducted to understand the mechanism for DAPE-induced apoptosis of NCI-H28 cells. DAPE induced caspase-independent...

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Bibliographic Details
Main Authors: Ayako Tsuchiya, Yoshiko Kaku, Takashi Nakano, Tomoyuki Nishizaki
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Journal of Pharmacological Sciences
Subjects:
1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine
Reactive oxygen species
Thioredoxin
Apoptosis signal-regulating kinase 1
p38 Mitogen-activated protein kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315002078

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http://www.sciencedirect.com/science/article/pii/S1347861315002078

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