Prodrugs Activated by Vascular Ectopeptidases: Proof of Concept
Several vascular ectopeptidases reside in blood vessels and efficiently regulate peptide hormones. For instance, bradykinin (BK) is inactivated by angiotensin converting enzyme (ACE) or arginine-carboxypeptidases (Arg-CPs), and aminopeptidase N (APN) cleaves several substrates. Whether such peptidas...
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| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
MDPI AG
2022-09-01
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| Серии: | Medical Sciences Forum |
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| Online-ссылка: | https://www.mdpi.com/2673-9992/14/1/89 |