Tirzepatide ameliorates spatial learning and memory impairment through modulation of aberrant insulin resistance and inflammation response in diabetic rats

Tirzepatide ameliorates spatial learning and memory impairment through modulation of aberrant insulin resistance and inflammation response in diabetic rats

Background: One of the typical symptoms of diabetes mellitus patients was memory impairment, which was followed by gradual cognitive deterioration and for which there is no efficient treatment. The anti-diabetic incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like p...

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Bibliographic Details
Main Authors: Xiying Guo, Min Lei, Jiangyan Zhao, Min Wu, Zhanhong Ren, Xiaosong Yang, Changhan Ouyang, Xiufen Liu, Chao Liu, Qingjie Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Pharmacology
Subjects:
tirzepatide
diabetes mellitus
spatial learning and memory
Aβ
synaptic plasticity
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1146960/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1146960/full

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