Osteocyte Apoptosis, Bone Marrow Adiposity, and Fibrosis in the Irradiated Human Mandible

Purpose: To assess the effect of radiation therapy on osteocyte apoptosis, osteocyte death, and bone marrow adipocytes in the human mandible and its contribution to the pathophysiology of radiation damage to the mandibular bone. Methods and Materials: Mandibular cancellous bone biopsies were taken f...

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Main Authors: Hannah Dekker, MD, DDS, Engelbert A.J.M. Schulten, MD, DDS, PhD, Inez Lichters, DDS, Leo van Ruijven, PhD, Huib W. van Essen, BSc, Gerrit-Jan Blom, MD, Elisabeth Bloemena, MD, PhD, Chris M. ten Bruggenkate, MD, DDS, PhD, Arja M. Kullaa, DDS, PhD, Nathalie Bravenboer, PhD
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Advances in Radiation Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2452109422000586