Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism.

Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism.

Indoleamine 2,3-dioxygenase (IDO) is found in multiple malignancies and exerts immunosuppressive effects that are central in protecting tumors from host T lymphocyte rejection. IDO is an enzyme involved in the catabolism of tryptophan resulting in inhibition of T lymphocyte function. While inhibitio...

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Bibliographic Details
Main Authors: Laïla-Aïcha Hanafi, Dominique Gauchat, Jessica Godin-Ethier, David Possamaï, Jean-Baptiste Duvignaud, Denis Leclerc, Nathalie Grandvaux, Réjean Lapointe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4050125?pdf=render

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http://europepmc.org/articles/PMC4050125?pdf=render

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