Single-chain tandem macrocyclic peptides as a scaffold for growth factor and cytokine mimetics

Single-chain tandem macrocyclic peptides as a scaffold for growth factor and cytokine mimetics

Peptides composed of two or more tandemly linked macrocyclic peptides binding to growth factor/cytokine receptors (STaMPtides) are useful growth factor/cytokine mimetics. The peptides can be produced from bacterial cells and bioactivity is demonstrated (HGF, EPO, TPO).

Bibliographic Details
Main Authors: Kenichiro Ito, Yoshihiko Matsuda, Ayako Mine, Natsuki Shikida, Kazutoshi Takahashi, Kyohei Miyairi, Kazutaka Shimbo, Yoshimi Kikuchi, Atsushi Konishi
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03015-6

Internet

https://doi.org/10.1038/s42003-022-03015-6

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