Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutations

Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutations

KRAS is the most commonly mutated oncogene in human cancers with limited therapeutic options, thus there is a critical need to identify novel targets and inhibiting agents. The 78-kDa glucose-regulated protein GRP78, which is upregulated in KRAS cancers, is an essential chaperone and the master regu...

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Bibliographic Details
Main Authors: Dat P. Ha, Bo Huang, Han Wang, Daisy Flores Rangel, Richard Van Krieken, Ze Liu, Soma Samanta, Nouri Neamati, Amy S. Lee
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
GRP78
KRAS
Lung cancer
Colon cancer
Pancreatic cancer
Small molecule inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S147655862200063X

Internet

http://www.sciencedirect.com/science/article/pii/S147655862200063X

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